… when trying to edit a Group Policy Preference which uses Item Level Targetting.
Using AGPM.
The underlying cause it that only AGPM 4.0 SP3 and later clients that support Windows 10. So if you are using an older AGPM client, you need to upgrade in order to safely edit Windows 10 Group Policies.
But to upgrade your AGPM client, you may need to upgrade your AGPM Server; both the AGPM install on the server and the Server Operating System.
The Microsoft advice is ambiguous.